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Genetics, environment and autism and their interaction
AbstractModern genetics has shown editing of messenger controlling protein structure and thereby function, and recombination also of proteins as well. Direct inhibitory effects of environmental inputs such as toxic minerals can furthermore inhibit key enzymes especially if containing SH groups as well as dietary overload of metabolites. Phenyl-ketonuria is a good model of possible interventions made possible by this knowledge, where mental retardation is prevented by removing excess of dietary phenyl-alanine. Complete removal of the genetic disposition is only possible by genetic engineering, However amelioration, sometimes even complete recovery from the symptoms , by removing toxic causes, or dietary overload, and, or activating key enzymes by cofactors is biochemically feasible.
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Dr Karl Reichelt University of Oslo, Norway
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